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casei IDCC 3451

Lessons from pharmacovigilance: pulmonary immune-related adverse events after immune checkpoint inhibitor therapy

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Oxidative Stress and Amyotrophic Lateral Sclerosis Presence of OS biomarkers and high levels of ROS have been determined in the CNS regions specifically in ALS patients (Golenia et al., 2014), which indicates that impaired redox homeostasis is a relevant factor and associated with the development and progression of neurodegeneration in fALS and sALS (Carr et al., 2015

In addition, alcohol consumption seems to preferentially activates specific subsets of hypothalamic POMC neurons projecting to the stress regulating areas such as the amygdala [154], and epigenetic modifications in the Pomc promoter region might partially explain the transgenerational effects of alcohol fetal exposure through early-life POMC molecular underpinning [155]

doi: 10.1093/annonc/mdu456